Drepanocytic anemia

Drepanocytic anemia is shown by the symptoms conected to thrombosis of organs vessels with erythrocytes of falciform shape and hemolytic anemia. It is genetic defect at which red bloody cells have a falciform shape, instead of usual disk-shaped.

Disease is hereditary, people are not recommended to marry drepanocytic anemia with each other. In the tropical countries falciform erythrocytes are affected with malaria and their carriers better survive in places of diffusion of this infection.

At initial stage of illness marrow is affected. There is a tumescence and pain because of thrombosis of organs vessels feeding a hip joint. Destruction of femur head with development of purulent infection is possible. The hemolytic crises (connected to mass destruction of erythrocytes) develop after infections and cause f death of patients with drepanocytic anemia.

In future hemolytic anemia threatens the patient constantly. An active hemopoiesis for replacement of losses leads to excessive development of marrow. There are characteristic changes of a skeleton: the bent backbone, tower skull, thin extremities. The liver and spleen are enlarged. Accumulation of iron in heart and other internals leads to heart failure, diabetes mellitus, cirrhosis. Trophic ulcers on legs are characteristic. There can be a stroke, paralysis of cranial nerves. The majority of patients with a serious form of anemia die within five years.

Drepanocytic anemia cannot be cured completely. Symptomatic antibiotics, blood transfusion and oxygen are applied.

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