Aplastic anemia (panmyelophthisis) is a specific illness of blood system with reduced formation of erythrocytes, granulocytes and thrombocytes in marrow. Together with an agranulocytosis and cytostatic illness refers to depressive illnesses of hematopoiesis.
The disease may develop at any age, usually after 50 years. Many drugs can become the reason: antibiotics (Levomycetinum, Streptomycin), Sulfanilamide, anti-inflammatory (Analgin), anti-tuberculous remedies (Isoniazid), cytostatic. Hemopoiesis is oppressed by chemicals: benzene, mercury vapors, oil products, physical factor is radiation are capable to cause aplastic anemia, endocrine and immune disturbances
In women having aplastic anemia can be found a cystic degeneration of ovaries, weakening of thyroid gland function. Sometimes aplastic anemia develops after infections: anginas, flu.
At research of marrow in it the quantity of blood making cells is sharply reduced, active marrow is replaced with fatty tissue. Sometimes marrow is absolutely “empty” – panmyelophthisis. It is reflected in condition of all organs. Atrophic changes develop in endocrine system – pituitary body, adrenals, ovaries, perhaps they are caused by the expressed hypoxia.
Aplastic anemia can be hereditary and acquired.